Assay Detail
Functional
CHEMBL872827
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Inhibition of dopamine reuptake ([3H]DA uptake) in rat cytosol
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.98 | 8.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20648 | — | — | 1 | 8.61 |
| CHEMBL35239 | — | — | 1 | 8.34 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.18 |
| CHEMBL353643 | — | — | 1 | 8.01 |
| CHEMBL369406 | — | — | 1 | 7.97 |
| CHEMBL110530 | — | — | 1 | 7.92 |
| CHEMBL424005 | — | — | 1 | 7.78 |
| CHEMBL159128 | — | — | 1 | 7.69 |
| CHEMBL39262 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20648 | — | IC50 | = | 2.48 | nM | 8.61 |
| CHEMBL35239 | — | IC50 | = | 4.58 | nM | 8.34 |
| CHEMBL281594 | VANOXERINE | IC50 | = | 6.63 | nM | 8.18 |
| CHEMBL353643 | — | IC50 | = | 9.73 | nM | 8.01 |
| CHEMBL369406 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL110530 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL424005 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL159128 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL39262 | — | IC50 | = | 49.6 | nM | 7.30 |