Assay Detail
Binding
CHEMBL872842
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Affinity at norepinephrine transporter (NET) in rat striatum, using [3H]- nisoxatine as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.00 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35239 | — | — | 1 | 6.47 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 6.30 |
| CHEMBL424005 | — | — | 1 | 6.16 |
| CHEMBL433733 | — | — | 1 | 6.04 |
| CHEMBL110530 | — | — | 1 | 6.03 |
| CHEMBL369406 | — | — | 1 | 5.99 |
| CHEMBL39262 | — | — | 1 | 5.96 |
| CHEMBL159128 | — | — | 1 | 5.58 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35239 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL281594 | VANOXERINE | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL424005 | — | IC50 | = | 691.0 | nM | 6.16 |
| CHEMBL433733 | — | IC50 | = | 921.0 | nM | 6.04 |
| CHEMBL110530 | — | IC50 | = | 945.0 | nM | 6.03 |
| CHEMBL369406 | — | IC50 | = | 1027.0 | nM | 5.99 |
| CHEMBL39262 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL159128 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL370805 | COCAINE | IC50 | = | 3530.0 | nM | 5.45 |