Assay Detail
Binding
CHEMBL872845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.59 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163221 | — | — | 1 | 10.00 |
| CHEMBL41632 | TIRATRICOL | 3.0 | 1 | 9.82 |
| CHEMBL46882 | — | — | 1 | 9.72 |
| CHEMBL350049 | — | — | 1 | 9.64 |
| CHEMBL164421 | — | — | 1 | 9.59 |
| CHEMBL163324 | — | — | 1 | 9.57 |
| CHEMBL159334 | — | — | 1 | 9.43 |
| CHEMBL161828 | — | — | 1 | 9.37 |
| CHEMBL423977 | — | — | 1 | 9.17 |
| CHEMBL159595 | — | — | 1 | 9.10 |
| CHEMBL350199 | — | — | 1 | 9.02 |
| CHEMBL161535 | — | — | 1 | 9.00 |
| CHEMBL348983 | — | — | 1 | 8.96 |
| CHEMBL434476 | — | — | 1 | 8.82 |
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 2 | 8.74 |
| CHEMBL159610 | — | — | 1 | 8.60 |
| CHEMBL163268 | — | — | 1 | 8.52 |
| CHEMBL346112 | — | — | 1 | 8.48 |
| CHEMBL163020 | — | — | 1 | 8.44 |
| CHEMBL163067 | — | — | 1 | 8.35 |
| CHEMBL163320 | — | — | 1 | 8.22 |
| CHEMBL264041 | — | — | 1 | 8.10 |
| CHEMBL161245 | — | — | 1 | 7.85 |
| CHEMBL441101 | — | — | 1 | 7.66 |
| CHEMBL559 | DEXTROTHYROXINE | 4.0 | 1 | 7.46 |
| CHEMBL163283 | — | — | 1 | 7.33 |
| CHEMBL350336 | — | — | 1 | 7.32 |
| CHEMBL163228 | — | — | 1 | 7.32 |
| CHEMBL163518 | — | — | 1 | 7.28 |
| CHEMBL163805 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163221 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL41632 | TIRATRICOL | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL46882 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL350049 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL164421 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL163324 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL159334 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL161828 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL423977 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL159595 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL350199 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL161535 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL348983 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL434476 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1544 | LIOTHYRONINE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL159610 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL163268 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL346112 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL163020 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1544 | LIOTHYRONINE | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL163067 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL163320 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL264041 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL161245 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL441101 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL559 | DEXTROTHYROXINE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL163283 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL350336 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL163228 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL163518 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL163805 | — | IC50 | = | 120.0 | nM | 6.92 |