Assay Detail
Binding
CHEMBL872877
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Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.39 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324017 | — | — | 1 | 9.52 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 6.89 |
| CHEMBL612083 | — | — | 1 | 6.64 |
| CHEMBL2092940 | — | — | 1 | 6.57 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 6.49 |
| CHEMBL111532 | — | — | 1 | 6.15 |
| CHEMBL109684 | — | — | 1 | 6.09 |
| CHEMBL1159663 | — | — | 1 | 5.31 |
| CHEMBL606939 | — | — | 1 | 5.19 |
| CHEMBL538023 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324017 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL24077 | (R)-SKF-38393 | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL612083 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL2092940 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL267930 | SPIPERONE | Ki | = | 323.0 | nM | 6.49 |
| CHEMBL111532 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL109684 | — | Ki | = | 804.0 | nM | 6.09 |
| CHEMBL1159663 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL606939 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL538023 | — | Ki | = | 10000.0 | nM | 5.00 |