Assay Detail
Binding
CHEMBL872909
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Binding affinity at rat 5-hydroxytryptamine 1B receptor by [3H]5-HT displacement.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.78 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276156 | — | — | 1 | 8.40 |
| CHEMBL9452 | — | — | 1 | 8.40 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 8.36 |
| CHEMBL9669 | — | — | 1 | 8.16 |
| CHEMBL9467 | — | — | 1 | 8.09 |
| CHEMBL9921 | — | — | 1 | 8.08 |
| CHEMBL9841 | — | — | 1 | 7.93 |
| CHEMBL273923 | — | — | 1 | 7.86 |
| CHEMBL9870 | — | — | 1 | 7.80 |
| CHEMBL9666 | — | — | 1 | 7.76 |
| CHEMBL275943 | — | — | 1 | 7.66 |
| CHEMBL9429 | — | — | 1 | 7.54 |
| CHEMBL269784 | — | — | 1 | 7.51 |
| CHEMBL267153 | — | — | 1 | 7.47 |
| CHEMBL9746 | — | — | 1 | 7.35 |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | 7.20 |
| CHEMBL269521 | MK-212 | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276156 | — | Ki | = | 3.98 | nM | 8.40 |
| CHEMBL9452 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL9669 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL9467 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL9921 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL9841 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL273923 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL9870 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL9666 | — | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL275943 | — | Ki | = | 21.8 | nM | 7.66 |
| CHEMBL9429 | — | Ki | = | 28.9 | nM | 7.54 |
| CHEMBL269784 | — | Ki | = | 30.8 | nM | 7.51 |
| CHEMBL267153 | — | Ki | = | 33.6 | nM | 7.47 |
| CHEMBL9746 | — | Ki | = | 44.6 | nM | 7.35 |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | = | 63.3 | nM | 7.20 |
| CHEMBL269521 | MK-212 | Ki | = | 178.0 | nM | 6.75 |