Assay Detail
Binding
CHEMBL872925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro affinity for 5-hydroxytryptamine 3 (5-HT3) receptor by displacement of [3H]BRL-43694 from rat entorhinal cortex
43
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 8.12 | 10.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160926 | — | — | 1 | 10.42 |
| CHEMBL285999 | — | — | 1 | 9.59 |
| CHEMBL289469 | GRANISETRON | 4.0 | 1 | 9.46 |
| CHEMBL1160920 | — | — | 1 | 9.38 |
| CHEMBL1160932 | — | — | 1 | 9.30 |
| CHEMBL1160929 | — | — | 1 | 9.21 |
| CHEMBL1160927 | — | — | 1 | 9.03 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 9.00 |
| CHEMBL113213 | — | — | 1 | 9.00 |
| CHEMBL1160928 | — | — | 1 | 8.80 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.80 |
| CHEMBL114100 | — | — | 1 | 8.70 |
| CHEMBL1160930 | — | — | 1 | 8.57 |
| CHEMBL333144 | — | — | 1 | 8.52 |
| CHEMBL1160925 | — | — | 1 | 8.47 |
| CHEMBL1160923 | — | — | 1 | 8.44 |
| CHEMBL1160924 | — | — | 1 | 8.43 |
| CHEMBL114093 | — | — | 1 | 8.40 |
| CHEMBL1160922 | — | — | 1 | 8.40 |
| CHEMBL114042 | — | — | 1 | 8.22 |
| CHEMBL114101 | — | — | 1 | 8.22 |
| CHEMBL609962 | — | — | 1 | 8.18 |
| CHEMBL114387 | — | — | 1 | 8.10 |
| CHEMBL1160921 | — | — | 1 | 8.07 |
| CHEMBL1160917 | — | — | 1 | 8.01 |
| CHEMBL111882 | — | — | 1 | 8.00 |
| CHEMBL333398 | — | — | 1 | 7.92 |
| CHEMBL1160919 | — | — | 1 | 7.72 |
| CHEMBL324719 | — | — | 2 | 7.60 |
| CHEMBL320994 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160926 | — | Ki | = | 0.038 | nM | 10.42 |
| CHEMBL285999 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL289469 | GRANISETRON | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL1160920 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL1160932 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1160929 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL1160927 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL46 | ONDANSETRON | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL113213 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1160928 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL56564 | TROPISETRON | Ki | = | 1.57 | nM | 8.80 |
| CHEMBL114100 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1160930 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL333144 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1160925 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL1160923 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1160924 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL114093 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1160922 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL114042 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL114101 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL609962 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL114387 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1160921 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL1160917 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL111882 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL333398 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1160919 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL324719 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL320994 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL326150 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL333834 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL115288 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL1160931 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL114921 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL112161 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL114569 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL117551 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1160918 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL117551 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL114911 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL325283 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL324719 | — | Ki | > | 10000.0 | nM | - |