Assay Detail
Functional
CHEMBL872947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against HeLa cervical carcinoma cells.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor agents. 2. Synthesis, structure-activity relationships, and biological evaluation of substituted 5H-pyridophenoxazin-5-ones with potent antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.47 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 7.40 |
| CHEMBL147140 | — | — | 1 | 7.40 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.16 |
| CHEMBL147017 | — | — | 1 | 7.10 |
| CHEMBL348701 | — | — | 1 | 7.00 |
| CHEMBL147392 | — | — | 1 | 7.00 |
| CHEMBL357353 | — | — | 1 | 7.00 |
| CHEMBL151875 | — | — | 1 | 6.92 |
| CHEMBL151423 | — | — | 1 | 6.70 |
| CHEMBL148592 | — | — | 1 | 6.70 |
| CHEMBL148576 | — | — | 1 | 6.52 |
| CHEMBL149774 | — | — | 1 | 6.30 |
| CHEMBL347271 | — | — | 1 | 5.85 |
| CHEMBL346174 | — | — | 1 | 5.57 |
| CHEMBL148722 | — | — | 1 | 5.11 |
| CHEMBL422497 | — | — | 1 | 5.11 |
| CHEMBL149317 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL147140 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL147017 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL348701 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL147392 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL357353 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL151875 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL151423 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL148592 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL148576 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL149774 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL347271 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL346174 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL148722 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL422497 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL149317 | — | IC50 | = | 8200.0 | nM | 5.09 |