Assay Detail
Functional
CHEMBL872954
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Inhibitory activity against human tumor cell line HT1080.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chromophore-modified antitumor anthracenediones: synthesis, DNA binding, and cytotoxic activity of 1,4-bis[(aminoalkyl)amino]benzo[g]-phthalazine-5,10-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.80 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542514 | — | — | 1 | 7.34 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.18 |
| CHEMBL542513 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542514 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL542513 | — | IC50 | = | 1300.0 | nM | 5.89 |