Assay Detail
Functional
CHEMBL872963
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Inhibitory concentration to reduce cell number to 50% in a panel of cultured, wild type human Jurkat leukemia (JL C) cells.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.07 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.02 |
| CHEMBL349474 | — | — | 1 | 7.77 |
| CHEMBL433703 | — | — | 1 | 7.68 |
| CHEMBL162885 | — | — | 1 | 7.55 |
| CHEMBL162739 | — | — | 1 | 7.36 |
| CHEMBL355827 | — | — | 1 | 7.13 |
| CHEMBL163525 | — | — | 1 | 7.10 |
| CHEMBL162112 | — | — | 1 | 7.03 |
| CHEMBL162987 | — | — | 1 | 7.01 |
| CHEMBL351244 | — | — | 1 | 6.80 |
| CHEMBL163577 | — | — | 1 | 6.78 |
| CHEMBL353127 | — | — | 1 | 6.71 |
| CHEMBL163072 | — | — | 1 | 6.50 |
| CHEMBL164407 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL349474 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL433703 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL162885 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL162739 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL355827 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL163525 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL162112 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL162987 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL351244 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL163577 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL353127 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL163072 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL164407 | — | IC50 | = | 2500.0 | nM | 5.60 |