Assay Detail
Functional
CHEMBL872984
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory concentration against formation of lipid peroxides in rat brain homogenates by thiobarbituric acid reactive substances (TBARS) assay according to the method of Stocks.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.14 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312901 | — | — | 1 | 5.96 |
| CHEMBL86670 | — | — | 1 | 5.74 |
| CHEMBL87037 | — | — | 1 | 5.58 |
| CHEMBL87809 | — | — | 1 | 5.47 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | 2.0 | 1 | 5.39 |
| CHEMBL47 | ALPHA-TOCOPHEROL | — | 1 | 5.33 |
| CHEMBL280070 | — | — | 1 | 5.03 |
| CHEMBL89729 | — | — | 1 | 5.00 |
| CHEMBL90392 | — | — | 1 | 4.93 |
| CHEMBL87041 | — | — | 1 | 4.71 |
| CHEMBL89879 | — | — | 1 | 4.62 |
| CHEMBL327228 | — | — | 1 | 4.59 |
| CHEMBL89474 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312901 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL86670 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL87037 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL87809 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL47 | ALPHA-TOCOPHEROL | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL280070 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL89729 | — | IC50 | = | 9940.0 | nM | 5.00 |
| CHEMBL90392 | — | IC50 | = | 11770.0 | nM | 4.93 |
| CHEMBL87041 | — | IC50 | = | 19380.0 | nM | 4.71 |
| CHEMBL89879 | — | IC50 | = | 23960.0 | nM | 4.62 |
| CHEMBL327228 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL89474 | — | IC50 | = | 32010.0 | nM | 4.50 |