Assay Detail
Binding
CHEMBL873047
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Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Syntheses and adrenergic activities of ring-fluorinated epinephrines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.66 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42359 | — | — | 1 | 6.16 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 5.82 |
| CHEMBL281232 | — | — | 1 | 5.82 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 5.70 |
| CHEMBL43711 | — | — | 1 | 4.78 |
| CHEMBL287587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42359 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL281232 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL43711 | — | Ki | = | 16500.0 | nM | 4.78 |
| CHEMBL287587 | — | Ki | > | 50000.0 | nM | - |