Assay Detail
Binding
CHEMBL873052
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Compound was evaluated for the inhibition of adenosine deaminase
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Adenosine deaminase inhibitors. Conversion of a single chiral synthon into erythro- and threo-9-(2-hydroxy-3-nonyl)adenines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.34 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1580 | PENTOSTATIN | 4.0 | 1 | 10.00 |
| CHEMBL284483 | COFORMYCIN | 2.0 | 1 | 10.00 |
| CHEMBL50378 | EHNA | — | 2 | 9.40 |
| CHEMBL296435 | (+)-EHNA | — | 1 | 8.70 |
| CHEMBL1555103 | — | — | 1 | 7.10 |
| CHEMBL2114367 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1580 | PENTOSTATIN | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL284483 | COFORMYCIN | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL50378 | EHNA | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL296435 | (+)-EHNA | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1555103 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL2114367 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL50378 | EHNA | Ki | = | 500.0 | nM | 6.30 |