Assay Detail
Binding
CHEMBL873060
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Binding affinity against recombinant Aminopeptidase A
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.37 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146746 | — | — | 1 | 9.06 |
| CHEMBL358903 | — | — | 1 | 8.49 |
| CHEMBL348205 | — | — | 1 | 8.45 |
| CHEMBL148777 | — | — | 1 | 8.44 |
| CHEMBL151631 | — | — | 1 | 8.42 |
| CHEMBL147285 | — | — | 1 | 8.37 |
| CHEMBL359101 | — | — | 1 | 8.27 |
| CHEMBL347763 | — | — | 1 | 8.03 |
| CHEMBL356858 | — | — | 1 | 7.92 |
| CHEMBL346397 | — | — | 1 | 7.89 |
| CHEMBL433935 | — | — | 1 | 7.83 |
| CHEMBL148482 | — | — | 1 | 7.82 |
| CHEMBL146922 | — | — | 1 | 7.80 |
| CHEMBL345941 | — | — | 1 | 7.70 |
| CHEMBL151900 | — | — | 1 | 7.57 |
| CHEMBL149449 | — | — | 1 | 7.40 |
| CHEMBL148781 | — | — | 1 | 7.30 |
| CHEMBL1161295 | — | — | 1 | 7.29 |
| CHEMBL149436 | — | — | 1 | 7.28 |
| CHEMBL357586 | — | — | 1 | 7.13 |
| CHEMBL1161305 | — | — | 1 | 7.10 |
| CHEMBL436269 | — | — | 1 | 7.08 |
| CHEMBL357167 | — | — | 1 | 6.96 |
| CHEMBL348192 | — | — | 1 | 6.84 |
| CHEMBL1161304 | — | — | 1 | 6.82 |
| CHEMBL151630 | — | — | 1 | 6.62 |
| CHEMBL344321 | — | — | 1 | 6.57 |
| CHEMBL149339 | — | — | 1 | 6.55 |
| CHEMBL149145 | — | — | 1 | 6.54 |
| CHEMBL147410 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146746 | — | Ki | = | 0.873 | nM | 9.06 |
| CHEMBL358903 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL348205 | — | Ki | = | 3.56 | nM | 8.45 |
| CHEMBL148777 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL151631 | — | Ki | = | 3.83 | nM | 8.42 |
| CHEMBL147285 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL359101 | — | Ki | = | 5.36 | nM | 8.27 |
| CHEMBL347763 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL356858 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL346397 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL433935 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL148482 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL146922 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL345941 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL151900 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL149449 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL148781 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1161295 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL149436 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL357586 | — | Ki | = | 73.3 | nM | 7.13 |
| CHEMBL1161305 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL436269 | — | Ki | = | 83.3 | nM | 7.08 |
| CHEMBL357167 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL348192 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL1161304 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL151630 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL344321 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL149339 | — | Ki | = | 283.0 | nM | 6.55 |
| CHEMBL149145 | — | Ki | = | 292.0 | nM | 6.54 |
| CHEMBL147410 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL149947 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL148746 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL146911 | — | Ki | = | 4200.0 | nM | 5.38 |