Assay Detail
Binding
CHEMBL873079
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Inhibition of in vitro enzyme activity measured in partially purified rat liver Histone deacetylase preparation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.37 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.92 |
| CHEMBL331150 | — | — | 1 | 6.89 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.78 |
| CHEMBL320038 | — | — | 1 | 6.58 |
| CHEMBL113003 | — | — | 1 | 6.54 |
| CHEMBL111993 | — | — | 1 | 6.51 |
| CHEMBL264629 | — | — | 1 | 6.50 |
| CHEMBL326617 | — | — | 1 | 6.48 |
| CHEMBL112652 | — | — | 1 | 6.42 |
| CHEMBL111919 | — | — | 1 | 6.41 |
| CHEMBL115271 | — | — | 1 | 6.39 |
| CHEMBL113095 | — | — | 1 | 6.34 |
| CHEMBL113337 | — | — | 1 | 6.29 |
| CHEMBL46941 | — | — | 1 | 6.10 |
| CHEMBL110906 | — | — | 1 | 6.10 |
| CHEMBL323695 | — | — | 1 | 6.10 |
| CHEMBL326022 | — | — | 1 | 6.08 |
| CHEMBL109960 | — | — | 1 | 6.06 |
| CHEMBL419029 | — | — | 1 | 6.00 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 1 | 5.94 |
| CHEMBL112728 | — | — | 1 | 5.87 |
| CHEMBL325733 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL331150 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL320038 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL113003 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL111993 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL264629 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL326617 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL112652 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL111919 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL115271 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL113095 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL113337 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL46941 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL110906 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL323695 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL326022 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL109960 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL419029 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL112728 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL325733 | — | IC50 | = | 1540.0 | nM | 5.81 |