Assay Detail
Functional
CHEMBL873084
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Compound was evaluated for the effect on DNA synthesis by HeLa cells in culture and the inhibition of [3H]- thymidine incorporation after 3h of addition
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, cell growth inhibition, and antitumor screening of 2-(p-n-butylanilino)purines and their nucleoside analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.41 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16122 | — | — | 1 | 4.64 |
| CHEMBL16119 | — | — | 1 | 4.52 |
| CHEMBL278903 | — | — | 1 | 4.50 |
| CHEMBL16103 | — | — | 1 | 4.46 |
| CHEMBL16129 | — | — | 1 | 4.40 |
| CHEMBL278248 | — | — | 1 | 4.33 |
| CHEMBL15985 | — | — | 1 | 4.28 |
| CHEMBL16193 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16122 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL16119 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL278903 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL16103 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL16129 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL278248 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL15985 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL16193 | — | IC50 | = | 69000.0 | nM | 4.16 |