Compound Detail
CHEMBL278248
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL278248 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FAYSZBMSWLHYEM-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
267.3
MW (Da)
3.39
ALogP
4
HBA
2
HBD
66.5
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.33
Ki 1 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DNA polymerase alpha catalytic subunit CHEMBL1828 | Ki | 5.3 | 5.3 | 5000.0 | 1 |
| HeLa CHEMBL399 | IC50 | 4.33 | 4.33 | 47000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DNA polymerase alpha catalytic subunit | Ki | = | 5000.0 | nM | 5.3 | Compound was evaluated for the concentration which gives half-maximal inhibition... | 3806587 |
| HeLa | IC50 | = | 47000.0 | nM | 4.33 | Compound was evaluated for the effect on DNA synthesis by HeLa cells in culture ... | 3806587 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3806587 | 10.1021/jm00384a019 | HeLa | 2 |
| 3806587 | 10.1021/jm00384a019 | DNA polymerase alpha catalytic subunit | 1 |
Data from ChEMBL 36 via Core Engine