Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL873199

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against human carbonic anhydrase I (hCA I)
ChEMBL ↗
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 1 (CHEMBL261) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.
Mincione F, Starnotti M, Menabuoni L, Scozzafava A, Casini A, Supuran CT.
Bioorg Med Chem Lett (2001) 11 : 1787 -1791
PubMed 11425561 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 65 6.78 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50128 — — 1 7.89
CHEMBL53407 — — 1 7.82
CHEMBL53607 — — 1 7.68
CHEMBL295343 — — 1 7.62
CHEMBL50365 — — 1 7.62
CHEMBL52550 — — 1 7.57
CHEMBL300020 — — 1 7.52
CHEMBL48292 — — 1 7.46
CHEMBL52375 — — 1 7.44
CHEMBL445615 — — 1 7.43
CHEMBL54235 — — 1 7.42
CHEMBL50000 — — 1 7.42
CHEMBL298755 — — 1 7.41
CHEMBL51506 — — 1 7.40
CHEMBL51668 — — 1 7.40
CHEMBL50045 — — 1 7.39
CHEMBL51719 — — 1 7.27
CHEMBL51455 — — 1 7.16
CHEMBL51456 — — 1 7.00
CHEMBL297706 — — 1 6.99
CHEMBL2113715 — — 1 6.98
CHEMBL52542 — — 1 6.94
CHEMBL51787 — — 1 6.90
CHEMBL51575 — — 1 6.89
CHEMBL299744 — — 1 6.87
CHEMBL301071 — — 1 6.82
CHEMBL51416 — — 1 6.77
CHEMBL51725 — — 1 6.76
CHEMBL51437 — — 1 6.70
CHEMBL48697 — — 1 6.69

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50128 — Ki = 13.0 nM 7.89
CHEMBL53407 — Ki = 15.0 nM 7.82
CHEMBL53607 — Ki = 21.0 nM 7.68
CHEMBL295343 — Ki = 24.0 nM 7.62
CHEMBL50365 — Ki = 24.0 nM 7.62
CHEMBL52550 — Ki = 27.0 nM 7.57
CHEMBL300020 — Ki = 30.0 nM 7.52
CHEMBL48292 — Ki = 35.0 nM 7.46
CHEMBL52375 — Ki = 36.0 nM 7.44
CHEMBL445615 — Ki = 37.0 nM 7.43
CHEMBL54235 — Ki = 38.0 nM 7.42
CHEMBL50000 — Ki = 38.0 nM 7.42
CHEMBL298755 — Ki = 39.0 nM 7.41
CHEMBL51668 — Ki = 40.0 nM 7.40
CHEMBL51506 — Ki = 40.0 nM 7.40
CHEMBL50045 — Ki = 41.0 nM 7.39
CHEMBL51719 — Ki = 54.0 nM 7.27
CHEMBL51455 — Ki = 69.0 nM 7.16
CHEMBL51456 — Ki = 100.0 nM 7.00
CHEMBL297706 — Ki = 103.0 nM 6.99
CHEMBL2113715 — Ki = 105.0 nM 6.98
CHEMBL52542 — Ki = 115.0 nM 6.94
CHEMBL51787 — Ki = 125.0 nM 6.90
CHEMBL51575 — Ki = 130.0 nM 6.89
CHEMBL299744 — Ki = 135.0 nM 6.87
CHEMBL301071 — Ki = 150.0 nM 6.82
CHEMBL51416 — Ki = 170.0 nM 6.77
CHEMBL51725 — Ki = 175.0 nM 6.76
CHEMBL51437 — Ki = 200.0 nM 6.70
CHEMBL48697 — Ki = 205.0 nM 6.69
CHEMBL297892 — Ki = 210.0 nM 6.68
CHEMBL298110 — Ki = 240.0 nM 6.62
CHEMBL295779 — Ki = 240.0 nM 6.62
CHEMBL51213 — Ki = 240.0 nM 6.62
CHEMBL49182 — Ki = 250.0 nM 6.60
CHEMBL50195 — Ki = 250.0 nM 6.60
CHEMBL50776 — Ki = 270.0 nM 6.57
CHEMBL300265 — Ki = 270.0 nM 6.57
CHEMBL50881 — Ki = 285.0 nM 6.54
CHEMBL48857 — Ki = 305.0 nM 6.52
CHEMBL51517 — Ki = 300.0 nM 6.52
CHEMBL296390 — Ki = 320.0 nM 6.50
CHEMBL51143 — Ki = 320.0 nM 6.50
CHEMBL2113714 — Ki = 350.0 nM 6.46
CHEMBL431742 — Ki = 350.0 nM 6.46
CHEMBL52227 — Ki = 380.0 nM 6.42
CHEMBL51346 — Ki = 400.0 nM 6.40
CHEMBL300436 — Ki = 400.0 nM 6.40
CHEMBL49062 — Ki = 405.0 nM 6.39
CHEMBL51200 — Ki = 410.0 nM 6.39