Assay Detail
Functional
CHEMBL873206
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In vitro inhibitory activity against LTB4 synthesis in A-23187 stimulated human whole blood (HB1).
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Oximes: A new class of methoxytetrahydropyranyl inhibitors of leukotriene biosynthesis with high in vitro and in vivo potency
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 6.88 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24925 | — | — | 1 | 7.70 |
| CHEMBL282308 | — | — | 1 | 7.70 |
| CHEMBL20403 | ZD-2138 | — | 1 | 7.60 |
| CHEMBL283654 | — | — | 1 | 7.52 |
| CHEMBL282775 | — | — | 1 | 7.40 |
| CHEMBL25692 | — | — | 1 | 7.40 |
| CHEMBL276958 | — | — | 1 | 7.40 |
| CHEMBL280554 | — | — | 1 | 7.40 |
| CHEMBL25097 | — | — | 1 | 7.40 |
| CHEMBL282773 | — | — | 1 | 7.40 |
| CHEMBL25348 | — | — | 1 | 7.40 |
| CHEMBL24239 | — | — | 1 | 7.40 |
| CHEMBL284403 | — | — | 1 | 7.40 |
| CHEMBL24087 | — | — | 1 | 7.40 |
| CHEMBL28275 | — | — | 1 | 7.30 |
| CHEMBL24358 | — | — | 1 | 7.30 |
| CHEMBL27285 | — | — | 1 | 7.22 |
| CHEMBL422226 | — | — | 1 | 7.22 |
| CHEMBL25570 | — | — | 1 | 7.10 |
| CHEMBL24973 | — | — | 1 | 7.05 |
| CHEMBL25401 | — | — | 1 | 7.00 |
| CHEMBL282816 | — | — | 1 | 6.96 |
| CHEMBL279716 | — | — | 1 | 6.92 |
| CHEMBL279935 | — | — | 1 | 6.92 |
| CHEMBL283523 | — | — | 1 | 6.89 |
| CHEMBL278364 | — | — | 1 | 6.85 |
| CHEMBL25627 | — | — | 1 | 6.85 |
| CHEMBL283905 | — | — | 1 | 6.82 |
| CHEMBL422047 | — | — | 1 | 6.80 |
| CHEMBL279746 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24925 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL282308 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL20403 | ZD-2138 | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL283654 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL24087 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL284403 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL24239 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL25348 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL282773 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL25097 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL280554 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL276958 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL25692 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL282775 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL24358 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL28275 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL27285 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL422226 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL25570 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL24973 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL25401 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL282816 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL279716 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL279935 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL283523 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL25627 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL278364 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL283905 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL422047 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL279746 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL282213 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL281329 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL27691 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL24975 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL281070 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL28066 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL27380 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL24030 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL26882 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL28221 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL27663 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL285137 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL283476 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL25039 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL25514 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL440843 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL25026 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL25142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL279240 | — | IC50 | > | 2500.0 | nM | - |