Assay Detail
Binding
CHEMBL873213
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Ionotropic glutamate receptor kainate using [3H]-Kainic acid as a radioligand
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic kainate (CHEMBL2109241) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.59 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308941 | — | — | 3 | 4.68 |
| CHEMBL72123 | — | — | 1 | - |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | - |
| CHEMBL423201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308941 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL308941 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL72123 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL308941 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 247000.0 | nM | - |
| CHEMBL423201 | — | IC50 | > | 100000.0 | nM | - |