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Assay Detail

CHEMBL873225

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Tissue Blood
Confidence 6 — Multiple protein complex / RNA
Curated By Expert

Target

5-lipoxygenase/FLAP (CHEMBL2111402)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

O-alkylcarboxylate oxime and N-hydroxyurea analogs of substituted indole leukotriene biosynthesis inhibitors
Woods KW, Brooks CD, Maki RG, Rodriques KE, Bouska JB, Young P, Bell RL, Carter GW
Bioorg Med Chem Lett (1996) 6 : 1547 -1552
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.26 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL289751 1 7.40
CHEMBL38958 1 7.30
CHEMBL39617 1 6.96
CHEMBL36331 1 6.75
CHEMBL16596 QUIFLAPON 2.0 1 6.70
CHEMBL38949 1 6.64
CHEMBL29097 1 6.47
CHEMBL38545 1 6.44
CHEMBL38884 1 6.22
CHEMBL38513 1 6.22
CHEMBL3349448 1 6.17
CHEMBL39473 1 6.08
CHEMBL434401 1 6.01
CHEMBL40073 1 5.96
CHEMBL290170 1 5.89
CHEMBL39189 1 5.80
CHEMBL3349449 1 5.66
CHEMBL444304 1 5.36
CHEMBL3349447 1 4.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL289751 IC50 = 40.0 nM 7.40
CHEMBL38958 IC50 = 50.0 nM 7.30
CHEMBL39617 IC50 = 110.0 nM 6.96
CHEMBL36331 IC50 = 180.0 nM 6.75
CHEMBL16596 QUIFLAPON IC50 = 200.0 nM 6.70
CHEMBL38949 IC50 = 230.0 nM 6.64
CHEMBL29097 IC50 = 340.0 nM 6.47
CHEMBL38545 IC50 = 360.0 nM 6.44
CHEMBL38884 IC50 = 600.0 nM 6.22
CHEMBL38513 IC50 = 600.0 nM 6.22
CHEMBL3349448 IC50 = 680.0 nM 6.17
CHEMBL39473 IC50 = 840.0 nM 6.08
CHEMBL434401 IC50 = 970.0 nM 6.01
CHEMBL40073 IC50 = 1090.0 nM 5.96
CHEMBL290170 IC50 = 1300.0 nM 5.89
CHEMBL39189 IC50 = 1600.0 nM 5.80
CHEMBL3349449 IC50 = 2200.0 nM 5.66
CHEMBL444304 IC50 = 4420.0 nM 5.36
CHEMBL3349447 IC50 = 11000.0 nM 4.96