Assay Detail
Binding
CHEMBL873237
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Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.60 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117130 | — | — | 1 | 7.82 |
| CHEMBL115713 | — | — | 1 | 7.80 |
| CHEMBL325193 | — | — | 1 | 7.62 |
| CHEMBL118860 | — | — | 2 | 7.58 |
| CHEMBL119110 | — | — | 1 | 7.12 |
| CHEMBL117031 | — | — | 1 | 7.03 |
| CHEMBL334213 | — | — | 1 | 6.85 |
| CHEMBL119760 | — | — | 1 | 6.85 |
| CHEMBL119349 | — | — | 1 | 6.85 |
| CHEMBL118265 | — | — | 1 | 6.70 |
| CHEMBL117973 | — | — | 1 | 6.64 |
| CHEMBL325198 | — | — | 1 | 6.62 |
| CHEMBL432809 | — | — | 1 | 6.23 |
| CHEMBL424254 | — | — | 1 | 6.22 |
| CHEMBL119562 | — | — | 1 | 6.19 |
| CHEMBL115738 | — | — | 1 | 6.10 |
| CHEMBL119233 | — | — | 1 | 6.08 |
| CHEMBL1160958 | — | — | 1 | 6.05 |
| CHEMBL118068 | — | — | 1 | 5.92 |
| CHEMBL334144 | — | — | 1 | 5.85 |
| CHEMBL116140 | — | — | 1 | 5.85 |
| CHEMBL421234 | — | — | 1 | 5.60 |
| CHEMBL119516 | — | — | 1 | 5.40 |
| CHEMBL119257 | — | — | 1 | - |
| CHEMBL117569 | — | — | 1 | - |
| CHEMBL432632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117130 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL115713 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL325193 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL118860 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL118860 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL119110 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL117031 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL334213 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL119760 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL119349 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL118265 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL117973 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL325198 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL432809 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL424254 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL119562 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL115738 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL119233 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1160958 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL118068 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL334144 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL116140 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL421234 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL119516 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL117569 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL119257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL432632 | — | IC50 | > | 10000.0 | nM | - |