Assay Detail
Binding
CHEMBL873307
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The compound was tested for inhibition of carboxyl protease (pepsin) inhibition
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effect of structure in subsite P3 on inhibition of pepsin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.44 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165448 | — | — | 1 | 9.74 |
| CHEMBL262137 | — | — | 1 | 9.51 |
| CHEMBL165690 | — | — | 1 | 8.80 |
| CHEMBL28738 | — | — | 1 | 8.54 |
| CHEMBL167297 | — | — | 1 | 8.12 |
| CHEMBL166522 | — | — | 1 | 8.07 |
| CHEMBL348724 | — | — | 1 | 7.96 |
| CHEMBL167093 | — | — | 1 | 6.77 |
| CHEMBL164635 | — | — | 1 | - |
| CHEMBL164716 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165448 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL262137 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL165690 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL28738 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL167297 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL166522 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL348724 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL167093 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL164635 | — | Ki | ~ | 0.1 | nM | - |
| CHEMBL164716 | — | Ki | ~ | 6.0 | nM | - |