Assay Detail
Binding
CHEMBL873373
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Compound was tested by chromogenic assay for the inhibition of serine proteases like Bovine trypsin
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.36 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108540 | — | — | 1 | 6.52 |
| CHEMBL108294 | — | — | 1 | 6.27 |
| CHEMBL109236 | — | — | 1 | 5.20 |
| CHEMBL111705 | — | — | 1 | 5.17 |
| CHEMBL320132 | — | — | 1 | 4.77 |
| CHEMBL320750 | — | — | 1 | 4.22 |
| CHEMBL320510 | — | — | 1 | - |
| CHEMBL432621 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108540 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL108294 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL109236 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL111705 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL320132 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL320750 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL320510 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL432621 | — | IC50 | = | 560000.0 | nM | - |