Assay Detail
Functional
CHEMBL873375
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TNF-alpha production in PBMC by ELISA method
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.66 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127042 | — | — | 1 | 5.30 |
| CHEMBL171989 | — | — | 1 | 5.30 |
| CHEMBL170479 | — | — | 1 | 5.22 |
| CHEMBL171406 | — | — | 1 | 5.00 |
| CHEMBL172669 | — | — | 1 | 4.96 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 4.92 |
| CHEMBL169239 | — | — | 1 | 4.92 |
| CHEMBL352725 | — | — | 1 | 4.82 |
| CHEMBL171179 | — | — | 1 | 4.80 |
| CHEMBL368458 | — | — | 1 | 4.75 |
| CHEMBL355042 | — | — | 1 | 4.72 |
| CHEMBL170920 | — | — | 1 | 4.70 |
| CHEMBL354257 | — | — | 1 | 4.60 |
| CHEMBL263480 | — | — | 1 | 4.60 |
| CHEMBL18701 | RO-201724 | — | 1 | 4.30 |
| CHEMBL423609 | — | — | 1 | 4.30 |
| CHEMBL174253 | — | — | 1 | 4.26 |
| CHEMBL169795 | — | — | 1 | 4.22 |
| CHEMBL174254 | — | — | 1 | 4.12 |
| CHEMBL628 | PENTOXIFYLLINE | 4.0 | 1 | 4.07 |
| CHEMBL170855 | — | — | 1 | 4.00 |
| CHEMBL172619 | — | — | 1 | - |
| CHEMBL172224 | — | — | 1 | - |
| CHEMBL170259 | — | — | 1 | - |
| CHEMBL171272 | — | — | 1 | - |
| CHEMBL355433 | — | — | 1 | - |
| CHEMBL354675 | — | — | 1 | - |
| CHEMBL170267 | — | — | 1 | - |
| CHEMBL170395 | — | — | 1 | - |
| CHEMBL1343 | 1-[4-CARBOXYPROPYL]-3,7-DIMETHYLXANTHINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127042 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL171989 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL170479 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL171406 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL172669 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL169239 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL352725 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL171179 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL368458 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL355042 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL170920 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL354257 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL263480 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL423609 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL18701 | RO-201724 | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL174253 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL169795 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL174254 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL628 | PENTOXIFYLLINE | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL170855 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL172619 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL172224 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL170259 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL171272 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL355433 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL354675 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL170267 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL170395 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL1343 | 1-[4-CARBOXYPROPYL]-3,7-DIMETHYLXANTHINE | IC50 | > | 200000.0 | nM | - |
| CHEMBL354263 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL171452 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL169882 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL368515 | — | IC50 | > | 200000.0 | nM | - |