Assay Detail
Binding
CHEMBL873436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the binding affinity towards muscarinic receptor in mouse brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2097162) ↗| Type | PROTEIN FAMILY |
| Organism | Mus musculus |
Publication
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.56 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34000 | — | — | 1 | 4.66 |
| CHEMBL33332 | — | — | 1 | 4.46 |
| CHEMBL289890 | — | — | 1 | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34000 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL33332 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL289890 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | IC50 | = | 170000.0 | nM | - |