Assay Detail
Binding
CHEMBL873475
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Binding affinity for 5-hydroxytryptamine 1B receptor
46
Total Activities
46
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.28 | 7.86 |
| -Log IC50 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301765 | — | — | 1 | 7.86 |
| CHEMBL27403 | — | — | 1 | 6.47 |
| CHEMBL51118 | — | — | 1 | 6.38 |
| CHEMBL62274 | — | — | 1 | 6.24 |
| CHEMBL261977 | — | — | 1 | 6.19 |
| CHEMBL293879 | — | — | 1 | 6.17 |
| CHEMBL54720 | — | — | 1 | 5.99 |
| CHEMBL64948 | — | — | 1 | 5.96 |
| CHEMBL63790 | — | — | 1 | 5.51 |
| CHEMBL302431 | — | — | 1 | 5.37 |
| CHEMBL294368 | — | — | 1 | 5.33 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 5.15 |
| CHEMBL292725 | — | — | 1 | 5.15 |
| CHEMBL63845 | — | — | 1 | 5.13 |
| CHEMBL65736 | — | — | 1 | 4.99 |
| CHEMBL65974 | — | — | 1 | 4.95 |
| CHEMBL418678 | — | — | 1 | 4.84 |
| CHEMBL62366 | — | — | 1 | 4.83 |
| CHEMBL63713 | — | — | 1 | 4.73 |
| CHEMBL62902 | — | — | 1 | 4.72 |
| CHEMBL64903 | — | — | 1 | 4.71 |
| CHEMBL302447 | — | — | 1 | 4.62 |
| CHEMBL65413 | — | — | 1 | 4.47 |
| CHEMBL62911 | — | — | 1 | 4.39 |
| CHEMBL64727 | — | — | 1 | 4.20 |
| CHEMBL63905 | — | — | 1 | 4.15 |
| CHEMBL65710 | — | — | 1 | 4.04 |
| CHEMBL66540 | — | — | 1 | - |
| CHEMBL66310 | — | — | 1 | - |
| CHEMBL64559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301765 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL27403 | — | IC50 | = | 338.84 | nM | 6.47 |
| CHEMBL51118 | — | IC50 | = | 416.87 | nM | 6.38 |
| CHEMBL62274 | — | IC50 | = | 575.44 | nM | 6.24 |
| CHEMBL261977 | — | IC50 | = | 645.65 | nM | 6.19 |
| CHEMBL293879 | — | IC50 | = | 676.08 | nM | 6.17 |
| CHEMBL54720 | — | IC50 | = | 1023.29 | nM | 5.99 |
| CHEMBL64948 | — | IC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL63790 | — | IC50 | = | 3090.3 | nM | 5.51 |
| CHEMBL302431 | — | IC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL294368 | — | IC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL18772 | QUIPAZINE | IC50 | = | 7079.46 | nM | 5.15 |
| CHEMBL292725 | — | IC50 | = | 7079.46 | nM | 5.15 |
| CHEMBL63845 | — | IC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL65736 | — | IC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL65974 | — | IC50 | = | 11220.18 | nM | 4.95 |
| CHEMBL418678 | — | IC50 | = | 14454.4 | nM | 4.84 |
| CHEMBL62366 | — | IC50 | = | 14791.08 | nM | 4.83 |
| CHEMBL63713 | — | IC50 | = | 18620.87 | nM | 4.73 |
| CHEMBL62902 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL64903 | — | IC50 | = | 19498.45 | nM | 4.71 |
| CHEMBL302447 | — | IC50 | = | 23988.33 | nM | 4.62 |
| CHEMBL65413 | — | IC50 | = | 33884.42 | nM | 4.47 |
| CHEMBL62911 | — | IC50 | = | 40738.03 | nM | 4.39 |
| CHEMBL64727 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL63905 | — | IC50 | = | 70794.58 | nM | 4.15 |
| CHEMBL65710 | — | IC50 | = | 91201.08 | nM | 4.04 |
| CHEMBL62445 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL66307 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL65669 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL302104 | — | -Log IC50 | - | — | - | |
| CHEMBL293219 | — | IC50 | = | 1380384.26 | nM | - |
| CHEMBL417570 | — | IC50 | = | 112201.85 | nM | - |
| CHEMBL68390 | — | -Log IC50 | - | — | - | |
| CHEMBL292293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63289 | — | -Log IC50 | - | — | - | |
| CHEMBL62612 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63588 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL66408 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52772 | — | IC50 | = | 1584893.19 | nM | - |
| CHEMBL303986 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63114 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL65212 | — | -Log IC50 | - | — | - | |
| CHEMBL64559 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL66310 | — | IC50 | = | 301995.17 | nM | - |
| CHEMBL66540 | — | IC50 | > | 100000.0 | nM | - |