Assay Detail
Functional
CHEMBL873543
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Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | SC-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.43 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199238 | — | — | 1 | 8.12 |
| CHEMBL370567 | — | — | 1 | 8.05 |
| CHEMBL197589 | LG-190178 | — | 1 | 7.72 |
| CHEMBL197548 | — | — | 1 | 6.09 |
| CHEMBL199122 | — | — | 1 | 6.00 |
| CHEMBL199131 | — | — | 1 | 6.00 |
| CHEMBL198213 | — | — | 1 | 5.92 |
| CHEMBL197946 | — | — | 1 | 5.72 |
| CHEMBL198651 | — | — | 1 | 5.46 |
| CHEMBL198037 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199238 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL370567 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL197589 | LG-190178 | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL197548 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL199122 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL199131 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL198213 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL197946 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL198651 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL198037 | — | IC50 | = | 6800.0 | nM | 5.17 |