Assay Detail
Binding
CHEMBL873596
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Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 10.20 | 10.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323464 | — | — | 1 | 10.36 |
| CHEMBL419367 | — | — | 1 | 10.26 |
| CHEMBL325581 | — | — | 1 | 10.15 |
| CHEMBL111277 | — | — | 1 | 10.11 |
| CHEMBL109644 | — | — | 1 | 10.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323464 | — | IC50 | = | 0.044 | nM | 10.36 |
| CHEMBL419367 | — | IC50 | = | 0.055 | nM | 10.26 |
| CHEMBL325581 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL111277 | — | IC50 | = | 0.078 | nM | 10.11 |
| CHEMBL109644 | — | IC50 | = | 0.077 | nM | 10.11 |