Assay Detail
Functional
CHEMBL873616
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.45 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301267 | ARTEMOTIL | 2.0 | 1 | 8.57 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.08 |
| CHEMBL319599 | — | — | 1 | 7.92 |
| CHEMBL93458 | — | — | 1 | 7.82 |
| CHEMBL93291 | — | — | 1 | 7.64 |
| CHEMBL92197 | — | — | 1 | 7.64 |
| CHEMBL96830 | — | — | 1 | 7.52 |
| CHEMBL92920 | — | — | 1 | 7.33 |
| CHEMBL91761 | — | — | 1 | 7.30 |
| CHEMBL278291 | WR-148999 | — | 1 | 7.26 |
| CHEMBL92507 | — | — | 1 | 7.12 |
| CHEMBL315158 | — | — | 1 | 7.08 |
| CHEMBL433368 | — | — | 1 | 6.96 |
| CHEMBL91857 | — | — | 1 | 6.85 |
| CHEMBL93301 | — | — | 1 | 6.70 |
| CHEMBL442960 | — | — | 1 | - |
| CHEMBL328771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301267 | ARTEMOTIL | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL319599 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL93458 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL93291 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL92197 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL96830 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL92920 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL91761 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL278291 | WR-148999 | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL92507 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL315158 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL433368 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL91857 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL93301 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL442960 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL328771 | — | IC50 | > | 300.0 | nM | - |