Assay Detail
Binding
CHEMBL873626
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The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.35 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293967 | — | — | 1 | 10.82 |
| CHEMBL53563 | — | — | 1 | 9.52 |
| CHEMBL301654 | — | — | 1 | 9.19 |
| CHEMBL473136 | — | — | 1 | 8.99 |
| CHEMBL54820 | — | — | 1 | 8.81 |
| CHEMBL293145 | — | — | 1 | 8.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293967 | — | IC50 | = | 0.015 | nM | 10.82 |
| CHEMBL53563 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL301654 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL473136 | — | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL54820 | — | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL293145 | — | IC50 | = | 1.65 | nM | 8.78 |