Assay Detail
Binding
CHEMBL873716
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Inhibitory activity against human carbonic anhydrase I
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.08 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307939 | — | — | 1 | 7.89 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.51 |
| CHEMBL75855 | — | — | 1 | 6.60 |
| CHEMBL76607 | — | — | 1 | 6.57 |
| CHEMBL74491 | — | — | 1 | 6.12 |
| CHEMBL305726 | — | — | 1 | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL265534 | — | — | 1 | 6.07 |
| CHEMBL77284 | — | — | 1 | 6.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL308631 | — | — | 1 | 6.01 |
| CHEMBL76563 | — | — | 1 | 6.01 |
| CHEMBL309592 | — | — | 1 | 5.97 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL75747 | — | — | 1 | 5.82 |
| CHEMBL76956 | — | — | 1 | 5.77 |
| CHEMBL75620 | — | — | 1 | 5.73 |
| CHEMBL76626 | — | — | 1 | 5.22 |
| CHEMBL306118 | — | — | 1 | 5.21 |
| CHEMBL77359 | — | — | 1 | 5.20 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307939 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL77517 | INDISULAM | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL75855 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL76607 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL74491 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL305726 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL265534 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL77284 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL308631 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL76563 | — | Ki | = | 975.0 | nM | 6.01 |
| CHEMBL309592 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL75747 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL76956 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL75620 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL76626 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL306118 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL77359 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |