Assay Detail
Functional
CHEMBL873726
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Binding affinity to I2-IBS, imidazoline binding site of MAO
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.98 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275970 | TRACIZOLINE | — | 1 | 8.72 |
| CHEMBL266386 | — | — | 1 | 7.95 |
| CHEMBL213439 | FURALINE | — | 1 | 7.68 |
| CHEMBL379643 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275970 | TRACIZOLINE | Ki | = | 1.905 | nM | 8.72 |
| CHEMBL266386 | — | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL213439 | FURALINE | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL379643 | — | Ki | = | 28.18 | nM | 7.55 |