Compound Detail
CHEMBL266386
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL266386 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SXZUZNSWIBDKGQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
198.3
MW (Da)
2.02
ALogP
2
HBA
1
HBD
24.4
PSA (Ų)
0.73
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nischarin CHEMBL3923 | Ki | 8.0 | 8.0 | 10.0 | 1 |
| Monoamine oxidase CHEMBL2095196 | Ki | 7.95 | 7.95 | 11.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nischarin | Ki | = | 10.0 | nM | 8.0 | Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relat... | 10737743 |
| Monoamine oxidase | Ki | = | 11.22 | nM | 7.95 | Binding affinity to I2-IBS, imidazoline binding site of MAO | 16942031 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16942031 | 10.1021/jm060605r | Monoamine oxidase | 3 |
| 10737743 | 10.1021/jm991124t | Nischarin | 1 |
Data from ChEMBL 36 via Core Engine