Assay Detail
Functional
CHEMBL873878
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Concentration required to inhibit the entry of HIV-1 reporter virus [ADA] into U-87 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | U-87 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.72 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105821 | — | — | 1 | 9.70 |
| CHEMBL109158 | — | — | 1 | 9.30 |
| CHEMBL323172 | — | — | 1 | 9.30 |
| CHEMBL78535 | ANCRIVIROC | 2.0 | 1 | 9.22 |
| CHEMBL105784 | — | — | 1 | 9.22 |
| CHEMBL112686 | — | — | 1 | 8.92 |
| CHEMBL324643 | — | — | 1 | 8.89 |
| CHEMBL2111747 | — | — | 1 | 8.82 |
| CHEMBL112760 | — | — | 1 | 8.55 |
| CHEMBL106767 | — | — | 1 | 8.40 |
| CHEMBL292625 | — | — | 1 | 8.26 |
| CHEMBL106098 | — | — | 1 | 8.25 |
| CHEMBL331140 | — | — | 1 | 8.04 |
| CHEMBL106247 | — | — | 1 | 8.00 |
| CHEMBL106209 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105821 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL109158 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL323172 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL78535 | ANCRIVIROC | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL105784 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL112686 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL324643 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2111747 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL112760 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL106767 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL292625 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL106098 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL331140 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL106247 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL106209 | — | IC50 | = | 13.0 | nM | 7.89 |