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Assay Detail

CHEMBL873897

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Substance-K receptor (CHEMBL2327)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Spatial requirements of the antagonist binding site of the NK2 receptor.
Ali MA, Bhogal N, Fishwick CW, Findlay JB.
Bioorg Med Chem Lett (2001) 11 : 819 -822
PubMed 11277528 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.66 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL60064 4-BENZENESULFINYLMETHYL-1-[2-(5-FLUORO-1H-INDOL-3-YL)-ETHYL]-PIPERIDIN-4-OL (STRUCTURAL MIX) 1 7.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL60064 4-BENZENESULFINYLMETHYL-1-[2-(5-FLUORO-1H-INDOL-3-YL)-ETHYL]-PIPERIDIN-4-OL (STRUCTURAL MIX) IC50 = 22.0 nM 7.66