Assay Detail
Functional
CHEMBL873898
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit polymerization of tubulin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.46 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL47426 | — | — | 1 | 5.89 |
| CHEMBL169298 | — | — | 1 | 5.85 |
| CHEMBL312992 | — | — | 1 | 5.77 |
| CHEMBL355523 | — | — | 1 | 5.18 |
| CHEMBL423439 | — | — | 1 | 5.17 |
| CHEMBL354644 | — | — | 1 | 5.09 |
| CHEMBL424367 | — | — | 1 | 4.80 |
| CHEMBL169800 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL47426 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL169298 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL312992 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL355523 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL423439 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL354644 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL424367 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL169800 | — | IC50 | > | 100000.0 | nM | - |