Assay Detail
Binding
CHEMBL873914
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Binding affinity towards rat Opioid receptor kappa 1 expressed in CHO cells of chinese hamster ovary was determined using [3H]diprenorphine as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effects of the substitution of Phe4 in the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.61 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405057 | — | — | 1 | 9.96 |
| CHEMBL412228 | — | — | 1 | 9.21 |
| CHEMBL385696 | — | — | 1 | 9.05 |
| CHEMBL430081 | — | — | 1 | 8.76 |
| CHEMBL441198 | — | — | 1 | 8.49 |
| CHEMBL262310 | — | — | 1 | 8.33 |
| CHEMBL407084 | — | — | 1 | 8.05 |
| CHEMBL262838 | — | — | 1 | 8.02 |
| CHEMBL429351 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405057 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL412228 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL385696 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL430081 | — | Ki | = | 1.73 | nM | 8.76 |
| CHEMBL441198 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL262310 | — | Ki | = | 4.69 | nM | 8.33 |
| CHEMBL407084 | — | Ki | = | 8.91 | nM | 8.05 |
| CHEMBL262838 | — | Ki | = | 9.54 | nM | 8.02 |
| CHEMBL429351 | — | Ki | = | 26.5 | nM | 7.58 |