Assay Detail
Binding
CHEMBL873946
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Inhibition of Mixed lineage kinase 1 (MLK1)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Mitogen-activated protein kinase kinase kinase 9 (CHEMBL2872) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mixed lineage kinase activity of indolocarbazole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.26 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289772 | — | — | 1 | 7.82 |
| CHEMBL288817 | — | — | 1 | 7.80 |
| CHEMBL277817 | — | — | 1 | 7.72 |
| CHEMBL288229 | — | — | 1 | 7.55 |
| CHEMBL290352 | CEP-1347 | 3.0 | 1 | 7.42 |
| CHEMBL36891 | — | — | 1 | 7.37 |
| CHEMBL288816 | — | — | 1 | 7.35 |
| CHEMBL37529 | — | — | 1 | 7.05 |
| CHEMBL288818 | — | — | 1 | 6.79 |
| CHEMBL29709 | — | — | 1 | 6.52 |
| CHEMBL38338 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289772 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL288817 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL277817 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL288229 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL290352 | CEP-1347 | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL36891 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL288816 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL37529 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL288818 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL29709 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL38338 | — | IC50 | = | 360.0 | nM | 6.44 |