Assay Detail
Binding
CHEMBL873984
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Inhibition of thrombin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.50 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83260 | — | — | 1 | 8.92 |
| CHEMBL79245 | — | — | 1 | 8.46 |
| CHEMBL313769 | — | — | 1 | 8.10 |
| CHEMBL84084 | — | — | 1 | 7.70 |
| CHEMBL309298 | — | — | 1 | 7.50 |
| CHEMBL408553 | — | — | 1 | 7.26 |
| CHEMBL404654 | — | — | 1 | 7.26 |
| CHEMBL310722 | — | — | 1 | 7.26 |
| CHEMBL83001 | — | — | 1 | 7.10 |
| CHEMBL82753 | — | — | 1 | 6.89 |
| CHEMBL83437 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83260 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL79245 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL313769 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL84084 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL309298 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL408553 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL404654 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL310722 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL83001 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL82753 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL83437 | — | Ki | = | 825.0 | nM | 6.08 |