Assay Detail
Binding
CHEMBL874031
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In vitro inhibitory constant against factor Xa (FXa) was tested
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.62 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416912 | — | — | 1 | 7.12 |
| CHEMBL19666 | — | — | 1 | 7.02 |
| CHEMBL19453 | — | — | 1 | 6.82 |
| CHEMBL19798 | — | — | 1 | 6.75 |
| CHEMBL19599 | CVS-2139 | — | 1 | 6.72 |
| CHEMBL279199 | — | — | 1 | 6.60 |
| CHEMBL431292 | CVS-2359 | — | 1 | 6.17 |
| CHEMBL19831 | — | — | 1 | 5.74 |
| CHEMBL19037 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416912 | — | Ki | = | 76.8 | nM | 7.12 |
| CHEMBL19666 | — | Ki | = | 96.4 | nM | 7.02 |
| CHEMBL19453 | — | Ki | = | 152.7 | nM | 6.82 |
| CHEMBL19798 | — | Ki | = | 178.6 | nM | 6.75 |
| CHEMBL19599 | CVS-2139 | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL279199 | — | Ki | = | 248.6 | nM | 6.60 |
| CHEMBL431292 | CVS-2359 | Ki | = | 674.0 | nM | 6.17 |
| CHEMBL19831 | — | Ki | = | 1810.0 | nM | 5.74 |
| CHEMBL19037 | — | Ki | > | 338.0 | nM | - |