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Assay Detail

CHEMBL874032

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was evaluated for the inhibition of glycogen phosphorylase
23
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Prediction of ligand-receptor binding thermodynamics by free energy force field three-dimensional quantitative structure-activity relationship analysis: applications to a set of glucose analogue inhibitors of glycogen phosphorylase.
Venkatarangan P, Hopfinger AJ.
J Med Chem (1999) 42 : 2169 -2179
PubMed 10377222 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 4.29 4.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3351143 1 4.50
CHEMBL3351142 1 4.41
CHEMBL3351147 1 4.36
CHEMBL3351132 1 4.35
CHEMBL3351140 1 4.09
CHEMBL3351139 1 4.03
CHEMBL442951 1 -
CHEMBL35946 2 -
CHEMBL3351138 1 -
CHEMBL32101 1 -
CHEMBL3351150 1 -
CHEMBL2303667 1 -
CHEMBL288091 1 -
CHEMBL133447 1 -
CHEMBL1222250 DEXTROSE 4.0 2 -
CHEMBL305283 1 -
CHEMBL334655 1 -
CHEMBL35757 2 -
CHEMBL71477 1 -
CHEMBL32498 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3351143 Ki = 32000.0 nM 4.50
CHEMBL3351142 Ki = 39000.0 nM 4.41
CHEMBL3351147 Ki = 44000.0 nM 4.36
CHEMBL3351132 Ki = 45000.0 nM 4.35
CHEMBL3351140 Ki = 81000.0 nM 4.09
CHEMBL3351139 Ki = 94000.0 nM 4.03
CHEMBL442951 Ki = 24700000.0 nM -
CHEMBL35946 Ki = 36700000.0 nM -
CHEMBL3351138 Ki = 140000.0 nM -
CHEMBL32101 Ki = 1500000.0 nM -
CHEMBL3351150 Ki = 370000.0 nM -
CHEMBL32498 Ki = 5400000.0 nM -
CHEMBL35946 Ki = 160000.0 nM -
CHEMBL288091 Ki = 1000000.0 nM -
CHEMBL133447 Ki = 9000000.0 nM -
CHEMBL1222250 DEXTROSE Ki = 1700000.0 nM -
CHEMBL305283 Ki = 53100000.0 nM -
CHEMBL1222250 DEXTROSE Ki = 7400000.0 nM -
CHEMBL334655 Ki = 400000.0 nM -
CHEMBL35757 Ki = 370000.0 nM -
CHEMBL71477 Ki = 34500000.0 nM -
CHEMBL35757 Ki = 440000.0 nM -
CHEMBL2303667 Ki = 15800000.0 nM -