Assay Detail
Binding
CHEMBL874034
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]dexamethasone as radioligand in SF-1 cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | SF-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.90 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273658 | — | — | 1 | 9.24 |
| CHEMBL8140 | — | — | 1 | 9.02 |
| CHEMBL8007 | — | — | 1 | 8.72 |
| CHEMBL7655 | — | — | 1 | 8.70 |
| CHEMBL267231 | — | — | 1 | 8.66 |
| CHEMBL7781 | — | — | 1 | 8.64 |
| CHEMBL268239 | — | — | 1 | 8.64 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.62 |
| CHEMBL266282 | AL-43 | — | 1 | 8.60 |
| CHEMBL7843 | — | — | 1 | 8.55 |
| CHEMBL7988 | — | — | 1 | 8.42 |
| CHEMBL7817 | — | — | 1 | 8.39 |
| CHEMBL8360 | — | — | 1 | 8.38 |
| CHEMBL267940 | — | — | 1 | 8.36 |
| CHEMBL8394 | — | — | 1 | 8.28 |
| CHEMBL7987 | — | — | 1 | 8.27 |
| CHEMBL8027 | — | — | 1 | 8.27 |
| CHEMBL8637 | — | — | 1 | 8.18 |
| CHEMBL7671 | — | — | 1 | 8.16 |
| CHEMBL440454 | — | — | 1 | 8.15 |
| CHEMBL8209 | — | — | 1 | 8.03 |
| CHEMBL8329 | — | — | 1 | 7.92 |
| CHEMBL274208 | — | — | 1 | 7.92 |
| CHEMBL266488 | — | — | 1 | 7.86 |
| CHEMBL267670 | — | — | 1 | 7.75 |
| CHEMBL266709 | — | — | 1 | 7.56 |
| CHEMBL415309 | — | — | 1 | 7.47 |
| CHEMBL8639 | — | — | 1 | 7.47 |
| CHEMBL8055 | — | — | 1 | 7.29 |
| CHEMBL8026 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273658 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL8140 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL8007 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL7655 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL267231 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL7781 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL268239 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL131 | PREDNISOLONE | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL266282 | AL-43 | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL7843 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL7988 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL7817 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL8360 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL267940 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL8394 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL7987 | — | Ki | = | 5.42 | nM | 8.27 |
| CHEMBL8027 | — | Ki | = | 5.32 | nM | 8.27 |
| CHEMBL8637 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL7671 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL440454 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL8209 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL8329 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL274208 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL266488 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL267670 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL266709 | — | Ki | = | 27.6 | nM | 7.56 |
| CHEMBL8639 | — | Ki | = | 33.8 | nM | 7.47 |
| CHEMBL415309 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL8055 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL8026 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL8139 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL8340 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL7844 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL7966 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL8359 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL8131 | — | Ki | = | 6000.0 | nM | 5.22 |