Assay Detail
Binding
CHEMBL874043
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Inhibitory activity against Monoamine oxidase B from rat brain mitochondria
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Mitochondria |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.58 | 4.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332229 | — | — | 1 | 4.94 |
| CHEMBL421088 | — | — | 1 | 4.68 |
| CHEMBL124867 | — | — | 1 | 4.56 |
| CHEMBL340952 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332229 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL421088 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL124867 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL340952 | — | IC50 | = | 74800.0 | nM | 4.13 |