Assay Detail
Functional
CHEMBL874049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of 40 uM NMDA induced depolarization in mouse cortical slices.
18
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.34 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116889 | — | — | 3 | 6.82 |
| CHEMBL3348521 | — | — | 2 | 5.86 |
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 5.80 |
| CHEMBL173031 | — | — | 1 | 5.38 |
| CHEMBL325882 | — | — | 2 | 5.11 |
| CHEMBL3348568 | — | — | 1 | 5.11 |
| CHEMBL119980 | — | — | 1 | 5.08 |
| CHEMBL280850 | — | — | 1 | 4.46 |
| CHEMBL118327 | — | — | 1 | 4.44 |
| CHEMBL303126 | — | — | 2 | - |
| CHEMBL420355 | — | — | 1 | - |
| CHEMBL65631 | — | — | 1 | - |
| CHEMBL118537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116889 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3348521 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL39664 | SELFOTEL | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL116889 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL173031 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3348521 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL325882 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3348568 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL119980 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL116889 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL280850 | — | IC50 | = | 34400.0 | nM | 4.46 |
| CHEMBL118327 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL118537 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL303126 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL65631 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL420355 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL303126 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL325882 | — | IC50 | > | 100000.0 | nM | - |