Compound Detail
CHEMBL119980
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Basic Information
| ChEMBL ID | CHEMBL119980 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RDWJNTRIWLQDHX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
291.3
MW (Da)
1.03
ALogP
3
HBA
4
HBD
106.9
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.45
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 5.45 | 5.45 | 3557.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.08 | 5.08 | 8400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 3557.0 | nM | 5.45 | In vitro compound's ability to displace [3H]-CGS-19,755 binding as a measure of ... | 1404235 |
| Unchecked | IC50 | = | 8400.0 | nM | 5.08 | In vitro inhibition of 40 uM NMDA induced depolarization in mouse cortical slice... | 1404235 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1404235 | 10.1021/jm00097a012 | Glutamate NMDA receptor | 1 |
| 1404235 | 10.1021/jm00097a012 | Unchecked | 1 |
| 1404235 | 10.1021/jm00097a012 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine