Assay Detail
Binding
CHEMBL744926
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro compound's ability to displace [3H]-CGS-19,755 binding as a measure of its affinity for the glutamate recognition site on the NMDA receptor complex.
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.27 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 7.27 |
| CHEMBL116889 | — | — | 1 | 7.26 |
| CHEMBL173031 | — | — | 1 | 6.97 |
| CHEMBL3348521 | — | — | 2 | 6.07 |
| CHEMBL119980 | — | — | 1 | 5.45 |
| CHEMBL325882 | — | — | 1 | 5.37 |
| CHEMBL326578 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL116889 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL173031 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3348521 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL3348521 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL119980 | — | IC50 | = | 3557.0 | nM | 5.45 |
| CHEMBL325882 | — | IC50 | = | 4298.0 | nM | 5.37 |
| CHEMBL326578 | — | IC50 | > | 10000.0 | nM | - |