Assay Detail
Binding
CHEMBL874161
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Inhibitory activity against matrix metalloprotease-3 (MMP3)
34
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.39 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 8.96 |
| CHEMBL125901 | — | — | 1 | 8.92 |
| CHEMBL125104 | — | — | 1 | 8.52 |
| CHEMBL126380 | — | — | 3 | 8.48 |
| CHEMBL340771 | — | — | 1 | 8.30 |
| CHEMBL339588 | — | — | 1 | 8.28 |
| CHEMBL125138 | — | — | 1 | 8.10 |
| CHEMBL126712 | — | — | 1 | 8.03 |
| CHEMBL126461 | — | — | 1 | 8.00 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.85 |
| CHEMBL127138 | — | — | 1 | 7.75 |
| CHEMBL337946 | — | — | 1 | 7.68 |
| CHEMBL340345 | — | — | 1 | 7.68 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.60 |
| CHEMBL126923 | — | — | 1 | 7.58 |
| CHEMBL340455 | — | — | 1 | 7.35 |
| CHEMBL123503 | — | — | 1 | 7.22 |
| CHEMBL339137 | — | — | 1 | 7.21 |
| CHEMBL127559 | — | — | 1 | 7.19 |
| CHEMBL127168 | — | — | 1 | 6.99 |
| CHEMBL338877 | — | — | 1 | 6.87 |
| CHEMBL127867 | — | — | 1 | 6.74 |
| CHEMBL127035 | — | — | 1 | 6.67 |
| CHEMBL127787 | — | — | 1 | 6.60 |
| CHEMBL126977 | — | — | 1 | 6.56 |
| CHEMBL339610 | — | — | 1 | 6.52 |
| CHEMBL337986 | — | — | 1 | 6.50 |
| CHEMBL126711 | — | — | 1 | 6.32 |
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | 6.28 |
| CHEMBL341249 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL125901 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL125104 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL126380 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL340771 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL339588 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL125138 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL126712 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL126461 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL127138 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL337946 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL340345 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL126923 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL340455 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL123503 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL339137 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL127559 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL126380 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL127168 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL338877 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL127867 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL127035 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL126380 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL127787 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL126977 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL339610 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL337986 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL126711 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL115653 | CIPEMASTAT | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL341249 | — | IC50 | = | 694.0 | nM | 6.16 |
| CHEMBL339315 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL125302 | — | IC50 | > | 100.0 | nM | - |