Assay Detail
Functional
CHEMBL874167
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The compound was tested for extracellular cytotoxicity against MDA MB 361(mammary carcinoma cell line) in the presence of stCPG2 prodrug
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-361 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Self-immolative anthracycline prodrugs for suicide gene therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.33 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.68 |
| CHEMBL311697 | — | — | 1 | 7.62 |
| CHEMBL311606 | — | — | 1 | 7.54 |
| CHEMBL407383 | — | — | 1 | 7.04 |
| CHEMBL83801 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL311697 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL311606 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL407383 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL83801 | — | IC50 | = | 177.0 | nM | 6.75 |