Assay Detail
Binding
CHEMBL874545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Melanin-concentrating hormone receptor 1 in diet-induced obese mice
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL4730) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.69 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179501 | — | — | 1 | 8.85 |
| CHEMBL193583 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179501 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL193583 | — | IC50 | = | 299.0 | nM | 6.52 |