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Assay Detail

CHEMBL874548

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against rat dipeptidyl peptidase IV
22
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Dipeptidyl peptidase 4 (CHEMBL4653)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents.
Ahn JH, Kim HM, Jung SH, Kang SK, Kim KR, Rhee SD, Yang SD, Cheon HG, Kim SS.
Bioorg Med Chem Lett (2004) 14 : 4461 -4465
PubMed 15357972 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.78 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL184335 1 7.22
CHEMBL184572 1 6.66
CHEMBL363542 1 6.44
CHEMBL361656 1 6.18
CHEMBL184651 1 6.10
CHEMBL369129 1 5.92
CHEMBL365291 1 5.92
CHEMBL184140 1 5.92
CHEMBL359848 1 5.89
CHEMBL362262 1 5.82
CHEMBL183721 1 5.72
CHEMBL429890 1 5.68
CHEMBL185923 2 5.68
CHEMBL184487 2 5.64
CHEMBL182300 1 5.58
CHEMBL183728 1 5.50
CHEMBL184631 1 5.37
CHEMBL362297 1 5.36
CHEMBL185222 1 5.28
CHEMBL184599 1 5.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL184335 IC50 = 60.0 nM 7.22
CHEMBL184572 IC50 = 220.0 nM 6.66
CHEMBL363542 IC50 = 360.0 nM 6.44
CHEMBL361656 IC50 = 660.0 nM 6.18
CHEMBL184651 IC50 = 800.0 nM 6.10
CHEMBL369129 IC50 = 1200.0 nM 5.92
CHEMBL365291 IC50 = 1200.0 nM 5.92
CHEMBL184140 IC50 = 1200.0 nM 5.92
CHEMBL359848 IC50 = 1300.0 nM 5.89
CHEMBL362262 IC50 = 1500.0 nM 5.82
CHEMBL183721 IC50 = 1900.0 nM 5.72
CHEMBL429890 IC50 = 2100.0 nM 5.68
CHEMBL185923 IC50 = 2100.0 nM 5.68
CHEMBL184487 IC50 = 2300.0 nM 5.64
CHEMBL182300 IC50 = 2600.0 nM 5.58
CHEMBL184487 IC50 = 2800.0 nM 5.55
CHEMBL183728 IC50 = 3200.0 nM 5.50
CHEMBL184631 IC50 = 4300.0 nM 5.37
CHEMBL362297 IC50 = 4400.0 nM 5.36
CHEMBL185222 IC50 = 5200.0 nM 5.28
CHEMBL184599 IC50 = 6400.0 nM 5.19
CHEMBL185923 IC50 = 24400.0 nM 4.61